Oral mucosa has the potential to give rise to reactive lesions that are non-neoplastic in nature. A wide variety of lesions differing from developmental to neoplastic type can be elicited. Lesions that arise in response to chronic irritation to the oral mucosa are referred to as reactive lesions. Agents like calculus, sharp cuspal tips, overhanging dental restorations, masochistic habits, ill-fitting prosthesis and appliances, and food impactions are the most common etiological factors. These lesions simulate each other in their clinical behavior. Therefore, it is of utmost importance to clinically correlate these lesions with histopathological features to avoid misdiagnosis of the conditions. The most commonly found lesions are traumatic fibroma (TF), pyogenic granuloma (PG), epulis fissuratum (EF), peripheral giant cell granuloma (PGCG).
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