In vitro Evidence of Dose-dependent Decrease of Uropathogenic E. coli after Consuming Commercial Cranberry Capsules in Type 2 Diabetic Premenopausal Adult Women: A Literature Review
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Dabas D. In vitro Evidence of Dose-dependent Decrease of Uropathogenic E. coli after Consuming Commercial Cranberry Capsules in Type 2 Diabetic Premenopausal Adult Women: A Literature Review. J Health Sci Res 2020; 11 (2):58-63.
Urinary tract infections (UTIs) arise due to the invasion of pathogenic microorganisms in the urinary tract, resulting in inflammatory reactions in the epithelial linings of the urinary tract. The presence of pathogenic bacteria colonization more than 100,000 microbes of the same strain per milliliter of the urine in two consecutive urine samples is said to be a positive specimen for infection. An electronic search was conducted by using the PubMed database of the library of Unitec Institute of Technology with key research terms “cranberry,” “urinary tract infections,” and “type 2 diabetes.” These specifications resulted in a number of research studies and review articles, but for this literature review, only random controlled trials, comparative studies, pilot studies, and controlled clinical trials were considered. A total of twelve studies were selected for this review, out of which nine were randomized controlled clinical trials, two were co-relational or observational studies, and one was pilot study. The search was not limited to studies on women; rather, an extensive search was carried out in other subpopulations like children, older age-group people, pregnant women, males, and healthy females that were carried out and published between 2008 and 2014. The random controlled trials in the present review provide level 2 evidence, observational studies provide level 4 evidence, and pilot studies provide level 6 evidence. These levels of evidences are mentioned according to the guidelines provided by Polit and Beck.
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