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VOLUME 6 , ISSUE 1 ( January-June, 2015 ) > List of Articles

RESEARCH ARTICLE

The Study of Relationship between Serum Magnesium and Glycated Hemoglobin in Clinically Uncomplicated Type 2 Diabetes Mellitus Patients

S Sushma, MS Kusuma Devi, S Naveen

Citation Information : Sushma S, Devi MK, Naveen S. The Study of Relationship between Serum Magnesium and Glycated Hemoglobin in Clinically Uncomplicated Type 2 Diabetes Mellitus Patients. J Health Sci Res 2015; 6 (1):1-4.

DOI: 10.5005/jp-journals-10042-1008

Published Online: 01-04-2016

Copyright Statement:  Copyright © 2015; The Author(s).


Abstract

Background

Studies have shown that low serum magnesium levels and microalbuminuria are associated with type 2 diabetes mellitus patients, which are the known predictors of risk for cardiovascular disease. The chief objective of this study is to evaluate the relationship between serum magnesium level with glycated hemoglobin and urine albumin levels in clinically uncomplicated type 2 diabetes mellitus patients.

Methodology

During this study, 35 were type 2 diabetes mellitus patients and 20 normal healthy subjects were age and sex matched, were evaluated for serum magnesium, urine albumin, glycated hemoglobin, fasting blood sugar, blood urea and serum creatinine levels.

Results

In 37% of the diabetic patients, magnesium concentrations were below the normal reference value. Micro albuminuria was seen in 60% of the diabetic cases. Serum magnesium level was correlated with glycemic control, as measured by HbA1c.

Conclusion

The findings of this study indicate that lower serum magnesium concentrations and microalbuminuria are common in type 2 diabetics. Low serum magnesium level was attributed to poor glycemic control in diabetics. Serum magnesium levels did not correlate with microalbuminuria among diabetics.

How to cite this article

Sushma S, Devi MSK, Naveen S. The Study of Relationship between Serum Magnesium and Glycated Hemoglobin in Clinically Uncomplicated Type 2 Diabetes Mellitus Patients. J Health Sci Res 2015;6(1):14.


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  1. Magnesium: the fifth but forgotten electrolyte. Am J Clin Pathol 1994;102:616622.
  2. Low plasma magnesium in type 2 diabetes. Swiss Med Wkly 2003;133:289292.
  3. Intestinal absorption of magnesium from food and supplements. J Clin Invest 1991;88(2):396402.
  4. Magnesium deficiency and diabetes mellitus. Current Science 2002;83(12):14561463.
  5. Micronutrient status in diabetes mellitus. Am J Physiology 1989;256:197202.
  6. Dietary magnesium depletion affects metabolic responses during submaximal exercise in postmenopausal women. J Nutr 2002;132(5):930935.
  7. Mag nesium deficiency produces insulin resistance and increased thromboxane synthesis. Hypertension 1993;21:10241029.
  8. Study of magnesium, glycosylated haemoglobin and lipid profile in diabetic retinopathy. Ind J Clin Biochem 2004;19(2):124127.
  9. Tietz text book of clinical biochemistry, 5th ed. Philadelphia: WB Saunders and Company; 2001.
  10. Insulin resistance and noninsulin dependent diabetes mellitus, cellular and molecular mechanisms. Am Jr Clin Nutr 1995;61(4):980986.
  11. Impaired insulininduced erythrocyte magnesium accumulation is correlated to impaired insulinmediated glucose disposal in type2 (non insulin dependent) diabetic patients. Diabetologia 1988;31:910915.
  12. Insulin resistance and hypomag nesaemia. Brit Med J 1982 Jul;24:255:262.
  13. Serum and dietary magnesium and the risk for type 2 diabetes mellitus. Arch Intern Med 1999;159(18):21502159.
  14. Prospective study of microalbuminuria as predica tor of mortality in NIDDM. Diabetes 1992;41(6):736741.
  15. Microalbuminuria, blood pressure, metabolic control and renal involvement: longitudinal studies in white noninsulindependent diabetic patients. Am J Hypertens 1997 Sept;10:18901895.
  16. Serum ionized magnesium levels in type 2 diabetic patients with microalbuminuria or clinical proteinuria. Am J Nephrol 2000;20(3):187192.
  17. Renal magnesium handling: new insights in understanding old problems. Kidney Int 1997;52(2):1180-1195.
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