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VOLUME 8 , ISSUE 2 ( July-December, 2017 ) > List of Articles


Associating Serum Iron and Magnesium Levels in Hypertensive and Chronic Periodontitis Patients: Do They have a Link?

Arati C Koregol, TJ Jerin Mary, Shivaraj Warad, Tejaswini Annam, Nitesh Kataria, Nagaraj B Kalburgi

Citation Information : Koregol AC, Mary TJ, Warad S, Annam T, Kataria N, Kalburgi NB. Associating Serum Iron and Magnesium Levels in Hypertensive and Chronic Periodontitis Patients: Do They have a Link?. J Health Sci Res 2017; 8 (2):61-65.

DOI: 10.5005/jp-journals-10042-1051

License: CC BY 3.0

Published Online: 01-08-2017

Copyright Statement:  Copyright © 2017; The Author(s).



Micronutrients have been extensively studied in recent years; of these magnesium and iron are essential for a variety of physiologic functions. Activation of neutrophils is an early effect of hypomagnesemia, which, in turn, causes periodontal tissue destruction. Since magnesium also influences blood pressure regulation by vascular tone and reactivity, its altered levels could contribute to the pathophysiology of hypertension. Iron plays a key role in the formation of reactive oxygen species that causes peroxidative damage to tissues.

Aims and objectives

The present study is designed to estimate the levels of serum iron and magnesium in healthy, chronic periodontitis patients with and without hypertension.

Materials and methods

This study includes 90 subjects, age ranging from 18 to 65 years. They were categorized into three groups as group I: 30 periodontally healthy, group II: 30 chronic periodontitis, and group III: 30 chronic periodontitis with hypertension. Serum magnesium levels were determined using the modified xylidyl blue reaction method and serum iron levels using ferrozine method without deproteinization via photometry.


Biochemical parameters showed mean serum iron levels in chronic periodontitis (59.17) to be significantly reduced as compared with the control group (76.90) and slightly increased in the chronic periodontitis with hypertension group (69.63). Serum magnesium levels were found to be significantly lower in the hypertensive group as compared with the chronic periodontitis and control groups.


Iron and magnesium have a link in the pathophysiology of periodontitis. Serum iron and serum magnesium levels were closely linked to periodontitis and hypertension.

How to cite this article

Kalburgi NB, Koregol AC, Mary TJJ, Warad S, Annam T, Kataria N. Associating Serum Iron and Magnesium Levels in Hypertensive and Chronic Periodontitis Patients: Do They have a Link? J Health Sci Res 2017;8(2):61-65.

  1. The key role of micronutrients. Clin Nutr 2006 Feb;25(1):1-13.
  2. Zinc and its importance for human health: an integrative review. J Res Med Sci 2013 Feb;18(2):144-157.
  3. Theodore Cooper Memorial Lecture. Hypertension and the pathogenesis of atherosclerosis. Oxidative stress and the mediation of arterial inflammatory response: a new perspective. Hypertension 1995 Feb;25(2):155-161.
  4. Inflammation and atherosclerosis. Circulation 2002 Mar;105(9):1135-1143.
  5. Essential hypertension. Part I: definition and etiology. Circulation 2000 Jan;101(3):329-335.
  6. Oral magnesium supplementation reduces ambulatory blood pressure in patients with mild hypertension. Am J Hypertens 2009 Oct;22(10):1070-1075.
  7. Iron, free radicals, and oxidative injury. Semin Hematol 1998 Jan;35(1):5-12.
  8. Cellular iron metabolism. Kidney Int Suppl 1999 Mar;55(69):S2-S11.
  9. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 1990 Feb;186:1-85.
  10. Everyone should be tested for iron disorder. J Am Diet Assoc 1992 Dec;92(12):1502-1509.
  11. New European, American and International guidelines for hypertension management: agreement and disagreement. Exp Rev Cardiovasc Ther 2004 May;2(3):359-368.
  12. Evaluation of blood parameters in patients with chronic periodontitis for signs of anemia. J Periodontol 2010 Aug;81(8):1202-1206.
  13. Anemia and periodontal disease—a correlative study. J Indian Dent Assoc 1971 Apr;43(4):67-78.
  14. Total erythrocyte, leucocyte and differential white cell counts of blood in chronic periodontitis disease. J Dent Res 1945 Oct;24:270-271.
  15. Ascorbic acid requirements in postoperative patients. Surg Gynecol Obstet 1978 Jul;149(1):49-55.
  16. Iron-regulatory proteins, iron-responsive elements and ferritin mRNA translation. Int J Biochem Cell Biol 1999 Oct;31(10):1139-1152.
  17. Lower numbers of erythrocytes and lower levels of hemoglobin in periodontitis patients compared to control subjects. J Clin Periodontol 2001 Oct;28(10):930-936.
  18. Interaction of inflammatory cytokines and erythropoietin in iron metabolism and erythropoiesis in anaemia of chronic disease. Clin Rheumatol 1995 Sep;14(5):519-525.
  19. ; Smith, JL.; Grodd, JL. Advanced nutrition and human metabolism. Belmont (CA): Thomson Wadsworth; 2005. p. 260-275.
  20. Use of antioxidants in the prevention and treatment of disease. J Int Fed Clin Chem 1998 Mar;10(1):21-23.
  21. Dental disease, fibrinogen and white cell count; links with myocardial infarction? Scott Med J 1993 Jun;38(3):73-74.
  22. Anemia is systematic cause of periodontal disease? J Periodontol 1968 Jan;39(1):35-38.
  23. Associations of medical status and physical fitness with periodontal disease. J Clin Periodontal 1996 Oct;26(10):664-672.
  24. A study to evaluate the status of vitamin C and iron in saliva and serum of patients with and without periodontal diseases. Int J Compr Adv Pharmacol 2016 Oct-Dec;1(1):5-9.
  25. Evaluation of micronutrient (zinc, copper and iron) levels in periodontitis patients with and without diabetes mellitus type 2: a biochemical study. Indian J Dent Res 2013 Jul-Aug;24(4):468-473.
  26. The relation between hypomagnesaemia and vascular stiffness in renal transplant recipients. Nephrology Dialysis Transplantation 2011;26(7): 2362—2369.
  27. Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium. Am J Hypertens 1997 Mar;10(3):346-355.
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