Journal of Health Sciences & Research

Register      Login

VOLUME 9 , ISSUE 2 ( December, 2018 ) > List of Articles

REVIEW ARTICLE

Honey as an Alternative in the Management of Contemporary Wound Healing: A Systematic Review

Dipika Dabas

Keywords : Burns, Healing, Honey, Manuka, Pain, Ulcers, Wound

Citation Information : Dabas D. Honey as an Alternative in the Management of Contemporary Wound Healing: A Systematic Review. J Health Sci Res 2018; 9 (2):41-48.

DOI: 10.5005/jp-journals-10042-1068

License: CC BY-NC 4.0

Published Online: 01-12-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction: In recent times, the traditional honey has shown a revival as a topical treatment for a variety of wounds. The aim of this systematic review is to assess the available evidence and further evaluate the role of honey in modern wound care management. Methods: The databases which were used for this purpose include the PubMed and the ISI web of science. The review only contains the studies being conducted on humans. The review only contains the studies being conducted on humans covering burns, ulcers and other types of wounds (like traumatic, postoperative, malignant wounds). Under “design,” research designs namely, RCTs and CCTs were included. Result: In all three of the identified wound types, honey as a dressing with healing promoting properties is supported by evidence, whereas, the other known properties of honey like debridement, deodorizing, anti-inflammatory and wound pain-reducing effects are found to be less supported by the pieces of evidence. Interpretation: Many limitations were quite evident in the included studies related to the methodology, quality, and sample size. This review tries to reveal all such limitations and gaps and also recommends certain suggestions forthe future research.


PDF Share
  1. World Health Organization. Traditional medicine: Fact sheet N134. 2008. Dec, [Last accessed on 2015 Oct 25]. Available from: http://www.who.int/mediacentre/factsheets/fs134/en/
  2. Thomas KJ, Nicoll JP, Coleman P. Use and expendture on complementary medicine in England: a population based survey. Complement Ther Med 2001;9:2-11.
  3. The Landmark report on public perceptions of alternative care. Sacramento: Landmark Healthcare Inc; 1998.
  4. Subrahmanyam M, Enoch S. Topical application of honey in the treatment of burns. In: Cooper R, Molan P, White R, editors. Honey in modern wound management. Aberdeen: HealthComm UK Limited, trading as Wounds UK Limited; 2009. p. 177-187.
  5. Bardy J, Slevin NJ, Mais KL, Molassiotis A. A systematic review of honey uses and its potential value within oncology care. Journal of clinical nursing. 2008 Oct;17(19):2604-2623.
  6. Dunford C. The use of honey-derived dressings to promote effective wound management. Professional nurse (London, England). 2005 Apr;20(8):35-38.
  7. Leigh Sare J. Leg ulcer management with topical medical honey. British journal of community nursing. 2008 Sep;13(Sup4):S22-S32.
  8. Zumla A, Lulat A. Honey—a remedy rediscovered. J R Soc Med. 1989 Jul; 82(7):384-385.
  9. Dany-Mazeau M, Pautard G. L'utilisation du miel dans le processus de cicatrisation. De la ruche a l'hopital. Krankenpflege Soins infirmiers. 1991;84(3):63-69.
  10. Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N. Honey as a topical treatment for wounds. Cochrane Database of Systematic Reviews. 2015(3).
  11. Lusby PE, Coombes A, Wilkinson JM. Honey: a potent agent for wound healing?. Journal of WOCN. 2002 Nov 1;29(6):295-300.
  12. Subrahmanyam M. Honey impregnated gauze versus polyurethane film (OpSiteR) in the treatment of burns.a prospective randomised study. British Journal of Plastic Surgery. 1993 Jan 1;46(4):322-323.
  13. Dealey C. Wound management products. In: The care of wounds. A guide for nurses, Third ed., Oxford, UK: Editorial offices: Blackwell Publishing Ltd.; 2005:83-89.
  14. Dealey C. German Wound Surgeons 1450-1750. EWMA Journal. 2005;5(2):48-51.
  15. Khan FR, Abadin ZU, Rauf N. Honey: nutritional and medicinal value. International journal of clinical practice. 2007 Oct;61(10):1705-1707.
  16. Langemo DK, Hanson D, Anderson J, Thompson P, Hunter S. Use of honey for wound healing. Advances in skin & wound care. 2009 Mar 1;22(3):113-118.
  17. Williamson DA, Lim A, Thomas MG, Baker MG, Roberts SA, Fraser JD, Ritchie SR. Incidence, trends and demographics of Staphylococcus aureus infections in Auckland, New Zealand, 2001.2011. BMC infectious diseases. 2013 Dec;13(1):569.
  18. Williamson DA, Zhang J, Ritchie S, Roberts S, Fraser J, Baker MG. Staphylococcus aureus disease in New Zealand, 200-
  19. Emerg Infect Dis, in press.
  20. Best Practice Advisory Committee. Management of impetigo.
  21. Available at http://www.bpac.org.nz/BPJ/2009/february/docs/bpj19_impetigo_pages_8-11.pdf
  22. Olaitan PB, Adeleke OE, Iyabo OO. Honey: a reservoir for microorganisms and an inhibitory agent for microbes. African health sciences. 2007;7(3).
  23. Robson V, Dodd S, Thomas S. Standardized antibacterial honey (Medihoney.) with standard therapy in wound care: randomized clinical trial. Journal of advanced nursing. 2009 Mar;65(3):565-575.
  24. Snowdon JA, Cliver DO. Microorganisms in honey. International journal of food microbiology. 1996 Aug 1;31(1-3):1-26.
  25. Anderson I. Honey dressings in wound care. Nurs Times 2006;102(22):40-42.
  26. Stephen-Haynes J. Evaluation of a honey-impregnated tulle dressing in primary care. British journal of community nursing. 2004 Jun;9(Sup2):S21-27.
  27. Ahmed AK, Hoekstra MJ, Hage JJ, Karim RB. Honeymedicated dressing: transformation of an ancient remedy into modern therapy. Annals of plastic surgery. 2003 Feb 1;50(2):143-148.
  28. Dunford C, Cooper R, Molan P, White R. The use of honey in wound management. Nursing Standard (through 2013). 2000 Nov 29;15(11):63-68.
  29. English HK, Pack AR, Molan PC. The effects of manuka honey on plaque and gingivitis: a pilot study. Journal of the International Academy of Periodontology. 2004 Apr;6(2):63-67.
  30. Jull A, Walker N, Parag V, Molan P, Rodgers A. Randomized clinical trial of honey-impregnated dressings for venous leg ulcers. British Journal of Surgery. 2008 Feb;95(2):175-182.
  31. Molan PC. Potential of honey in the treatment of wounds and burns. American journal of clinical dermatology. 2001 Feb 1;2(1):13-19.
  32. Gethin G, Cowman S. Retracted: Manuka honey vs. hydrogel. a prospective, open label, multicentre, randomised controlled trial to compare desloughing efficacy and healing outcomes in venous ulcers. Journal of clinical nursing. 2009 Feb;18(3):466-474.
  33. Gethin G, Cowman S. Bacteriological changes in sloughy venous leg ulcers treated with manuka honey or hydrogel: an RCT. Journal of wound care. 2008 Jun;17(6):241-247.
  34. Shukrimi A, Sulaiman AR, Halim AY, Azril A. A comparative study between honey and povidone iodine as dressing solution for Wagner type II diabetic foot ulcers. Med J Malaysia. 2008 Mar;63(1):44-46.
  35. Baghel PS, Shukla S, Mathur RK, Randa R. A comparative study to evaluate the effect of honey dressing and silver sulfadiazene dressing on wound healing in burn patients. Indian journal of plastic surgery: official publication of the Association of Plastic Surgeons of India. 2009 Jul;42(2):176-181.
  36. Malik KI, Malik MN, Aslam A. Honey compared with silver sulphadiazine in the treatment of superficial partialthickness burns. International Wound Journal. 2010 Oct 1;7(5):413-417.
  37. Subrahmanyam M. Topical application of honey in treatment of burns. British Journal of Surgery. 1991 Apr;78(4):497-498.
  38. Subrahmanyam M. Early tangential excision and skin grafting of moderate burns is superior to honey dressing: a prospective randomised trial. Burns. 1999 Dec 1;25(8):729-731.
  39. Subrahmanyam M. A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine. Burns. 1998 Mar 1;24(2): 157-161.
  40. Chang EH, Alandejani T, Akbari E, Ostry A, Javer A. Doubleblinded, randomized, controlled trial of medicated versus nonmedicated merocel sponges for functional endoscopic sinus surgery. J Otolaryngol Head Neck Surg. 2011 Feb 1;40(suppl 1):S14-19.
  41. Robson V, Yorke J, Sen RA, Lowe D, Rogers SN. Randomised controlled feasibility trial on the use of medical grade honey following microvascular free tissue transfer to reduce the incidence of wound infection. British Journal of Oral and Maxillofacial Surgery. 2012 Jun 1;50(4):321-327.
  42. Moolenaar M, Louwrens Poorter R, Paulus Gerardus Van Der Toorn P, Willem Lenderink A, Poortmans P, Cornelis Gerardus Egberts A. The effect of honey compared to conventional treatment on healing of radiotherapy-induced skin toxicity in breast cancer patients. 2006;45(5):623-624.
  43. Mphande AN, Killowe C, Phalira S, Wynn Jones H, Harrison WJ. Effects of honey and sugar dressings on wound healing. Journal of wound care. 2007 Jul;16(7):317-319.
  44. Khanal B, Baliga M, Uppal N. Effect of topical honey on limitation of radiation-induced oral mucositis: an intervention study. International journal of oral and maxillofacial surgery. 2010 Dec 1;39(12):1181-1185.
  45. Ingle R, Levin J, Polinder K. Wound healing with honey-a randomised controlled trial. South African Medical Journal. 2006;96(9):831-835.
  46. Al-Waili NS, Saloom KY. Effects of topical honey on postoperative wound infections due to gram positive and gram negative bacteria following caesarean sections and hysterectomies. European journal of medical research. 1999 Mar;4(3):126-130.
  47. Abdulrhman M, Samir Elbarbary N, Ahmed Amin D, Saeid Ebrahim R. Honey and a mixture of honey, beeswax, and olive oil.propolis extract in treatment of chemotherapy-induced oral mucositis: a randomized controlled pilot study. Pediatric hematology and oncology. 2012 Mar 30;29(3):285-292.
  48. Okeniyi JA, Olubanjo OO, Ogunlesi TA, Oyelami OA. Comparison of healing of incised abscess wounds with honey and EUSOL dressing. Journal of Alternative & Complementary Medicine. 2005 Jun 1;11(3):511-513. 47 Misirlioglu A, Eroglu S, Karacaoglan N, Akan M, Akoz T, Yildirim S. Use of honey as an adjunct in the healing of split-thickness skin graft donor site. Dermatologic surgery. 2003 Feb;29(2):168-172.
  49. Gunes UY, Eser I. Effectiveness of a honey dressing for healing pressure ulcers. Journal of Wound Ostomy & Continence Nursing. 2007 Mar 1;34(2):184-190.
  50. Tijani LA, Onyechi HU. A comparison of topical honey and phenytoin in the treatment of chronic leg ulcers. African journal of medicine and medical sciences. 2000 Mar;29(1):31-34.
  51. Lund-Nielsen B, Adamsen L, Kolmos HJ, Rorth M, Tolver A, Gottrup F. The effect of honey-coated bandages compared with silver-coated bandages on treatment of malignant wounds.a randomized study. Wound Repair and Regeneration. 2011 Nov;19(6):664-670.
  52. Subrahmanyam M. Honey dressing versus boiled potato peel in the treatment of burns: a prospective randomized study. Burns. 1996 Sep 1;22(6):491-493.
  53. Brusselaers N, Pirayesh A, Hoeksema H, Richters CD, Verbelen J, Beele H, Blot SI, Monstrey S. Skin replacement in burn wounds. Journal of Trauma and Acute Care Surgery. 2010 Feb 1;68(2):490-501.
  54. Dunford CE. Treatment of a wound infection in a patient with mantle cell lymphoma. British Journal of Nursing. 2001 Aug 13;10(16):1058-1065.
  55. Gottrup F, Apelqvist J, Price P, editors. Outcomes in controlled and comparative studies on non-healing wounds: recommendations to improve the quality of evidence in wound management. Journal of wound care. 2010 Jun;19(6): 237-268.
  56. McIntosh CD, Thomson CE. Honey dressing versus paraffin tulle gras following toenail surgery. Journal of wound care. 2006 Mar;15(3):133-136.
  57. Baghel PS, Shukla S, Mathur RK, Randa R. A comparative study to evaluate the effect of honey dressing and silver sulfadiazene dressing on wound healing in burn patients. Indian journal of plastic surgery: official publication of the Association of Plastic Surgeons of India. 2009 Jul;42(2): 176-181.
  58. Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC, Devereaux PJ, Elbourne D, Egger M, Altman DG. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. International journal of surgery. 2012 Jan 1;10(1):28-55.
  59. Wilkinson JM, Simpson MD. High use of complementary therapies in a New South Wales rural community. Aust J Rural Health 2001;9:166-171.
  60. White R. The benefits of honey in wound management. Nursing Standard. 2005 Nov 16;20(10):57-66.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.