INTRODUCTION

Ludwig’s angina is a rapidly progressive, potentially fulminant cellulitis involving the sublingual, submental, and submandibular spaces. It may or may not involve parapharyngeal space.1

The word Angina is derived from the Latin word angere which means to strangle. Ludwig’s angina was coined after the German physician, Wilhelm Friedrich von Ludwig, who first described this condition in 1836 as a rapidly and frequently fatal progressive gangrenous cellulitis and edema of the soft tissues of the neck and floor of the mouth.2 Other synonyms include angina ludovici, cynanche, carbuculus gangraenosus, morbus strangulatorius and angina maligna.3

Despite the recent advances in therapy, rare and potentially life-threatening complications may still arise from time to time, and, as a result, account for significant morbidity and mortality. We present a case of Ludwig’s angina, successfully managed at our hospital, with a brief review.

CASE REPORT

A 55-year-old male presented with a chief complaint of inability to open the mouth, pain, and swelling in relation to the lower jaw and neck since a day. Patient revealed history of pain in left lower tooth region 4 days back and has taken treatment from local doctor (Tab. Combiflam twice a day), but the pain had not subsided. Past medical, dental, and family histories were noncontributory.

On physical examination, he had respiratory distress and was toxic in appearance and his vital signs were monitored immediately. His temperature was 101.3°F with a pulse rate of 104 beats per minute, blood pressure of 140/90 mmHg, and a respiratory rate of 27 breaths per minute.

On extraoral examination (Figs 1A and B), there was diffused swelling in the lower third of face measuring approximately 5 × 3 cm extending from left angle of mandible to right angle of mandible with bilateral involvement of the submandibular and sublingual spaces.

The overlying skin appeared reddish, stretched, and shiny. On palpation, the swelling was tender with elevated temperature. Patient had difficulty in breathing and restricted mouth-opening, with an interincisor gap of 1 cm.

Intraoral examination (Fig. 2A) revealed vestibular swelling and obliteration in the region of 35 (root stump) and 36 with pus discharge from gingival sulcus. Generalized attrition and gingival recession were noted. Orthopantamograph revealed (Fig. 2B) grossly destructed 46, 37, missing 26, and root stumps with 14, 18, 25, 35, 36. Depending on the history and clinical examination, a diagnosis of Ludwig’s angina was made. Patient was scheduled for emergency drainage (Figs 3A and B) of the abscess followed by intravenous injections of augmentin 1.2 gm twice a day, metrogyl 100 mg thrice a day, and intramuscular injection of voveran 75 mg once a day for 5 days. Patient was recalled after 5 days, the swelling was subsided, and patient was scheduled for further treatment with extraction of 35 and 36 (root stumps) followed by oral prophylaxis and replacement of missing teeth.

Figs 1A and B

Clinical images: (A) Pretreatment; and (B) posttreatment

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Figs 2A and B

(A) Intraoral view; and (B) orthopantamograph showing root piece with 35

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Figs 3A and B

Incision and drainage of pus

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DISCUSSION

Ludwig’s angina is a serious, potentially life-threatening cellulitis or connective tissue infection of the floor of the mouth that spreads to the structures of the anterior neck and beyond via connective tissue, muscle, and fascial planes rather than by the lymphatic system.3

About 80% of cases of Ludwig’s angina are odontogenic in etiology, primarily resulting from infections of the second and third molars. Predisposing factors include intravenous drug use, diabetes mellitus, systemic lupus erythematosus, acute glomerulonephritis aplastic anemia, neutropenia, dermatomyositis, alcoholism, malnutrition, a compromised immune system, organ transplantation, and trauma.4

The signs of Ludwig’s angina are bilateral involvement of lower facial swelling, pain, and erythema around the lower jaw and upper neck. This is because the infection has spread to involve the submandibular, sublingual, and submental spaces of the face.3 Swelling in these areas can often push the floor of the mouth, including the tongue upward and backward further compromising the airway. Intraorally, there will be elevation of the tongue, woody, brawny in duration of the floor of the mouth and anterior neck with a bilateral submandibular edema.

Asphyxia is caused by expanding edema of soft tissues of the neck. Additional symptoms include dysphagia, dysphonia, malaise, fever, tiredness, confusion, anxiousness, agitation, earache, drooling of saliva, and fetid breath. There may also be varying degrees of trismus, hoarseness, stridor, respiratory distress, decreased air movement, and cyanosis.5

Up to 65% of patients with Ludwig’s angina develop suppurative complications that require surgical drainage. Other complications of Ludwig’s angina include life-threatening airway narrowing or obstruction, cavernous sinus thrombosis, brain abscess, carotid sheath infection, arterial rupture, suppurative thrombophlebitis of the internal jugular vein, mediastinitis, empyema, lung abscess, pericardial and/or pleural effusion, osteomyelitis of the mandible, subphrenic abscess, septic shock, and aspiration pneumonia.6

Ludwig’s angina is a life-threatening condition and carries a fatality rate of about 5%. In keeping with this notion, hospitalization should be taken as the initial measure, and treatment should be based on three important aspects that include upper airway maintenance, drainage or surgical decompression, and intravenous antimicrobial therapy.2

Airway management is the foundation of treatment for patients with Ludwig’s angina. Recommended techniques include routine incision and drainage, orotracheal intubation, and fiber-optic nasotracheal intubation. A nasotracheal tube is sometimes warranted for ventilation, if the tissues of the mouth make insertion of an oral airway difficult or impossible. In the case of respiratory impairment, the patient should be admitted to the intensive care unit and orotracheal intubation should be postponed. Traditionally, aggressive airway management by securing the airway with endotracheal intubation or surgically with a surgical tracheostomy was the norm.7

The use of intravenous steroids has been proposed as a mean of reducing soft tissue swelling and edema and minimizing the likelihood for the need of a surgical airway in Ludwig’s angina. This remains controversial, as up to this date no randomized controlled trials that demonstrate the efficacy of corticosteroids in these patients exist.6

Antibiotics should be initiated as soon as possible. Antibiotics should initially be broad-spectrum and cover Gram-positive, Gram-negative, and anaerobic organisms. The antibiotic of choice is from the penicillin group. Recommended initial antibiotics are high-dose penicillin G, sometimes used in combination with an antistaphylococcal drug or metronidazole (Table 1).3

Larawin et al8 retrospectively studied a total of 103 patients with deep neck space infections from 1993 to 2005. Ludwig’s angina was the most commonly encountered infection seen in 38 (37%) patients of treatment. About 13 (34%) patients managed successfully with medical therapy and only 4 (10%) patients required a tracheostomy tube.

Kurien et al reported a 13-year review of patients with Ludwig’s angina between 1982 and 1995. Patients were either admitted to the ear–nose–throat or pediatric surgical units. There were 41 patients, 24% being children and 76% adults. In children, 70% were controlled with conservative medical management, while 81% of adults required incision and drainage. Tracheostomy was necessary in 10% of the children and 52% of the adults. Mortality rate was 10% in both groups.9

A 9-year review by Greenberg et al10 of 29 cases of deep neck space infections reported 21 patients (72 %) treated conservatively following initial clinical assessment.

Table 1: Management of Ludwig’s angina

Sl. no.Name of drug (injection)Dosage
 1Benzylpenicillin1.2 gm IV every 6 hours
 2MetronidazoleFlagyl 100 mg IV thrice daily for 5 days
 3Patients allergic to penicillin-clindamycin hydrochlorideCleocin HCl 450 mg IV every 8 hours
 4Amoxicillin-clavulanateAugmentin 1.2 gm IV BID twice daily for 5 days
 5Dexamethasone sodium phosphate(Decadron) 8–12 mg IV initially then of 4–8 mg every 6 hours given for 48 hours
 6Gentamicine40 mg IV twice daily for 5 days
 7Voveran75 mg once daily intramuscular
 8Cefoxitin sodiumCefoxil
 9Ticarcillin-clavulanateTimentin
10Piperacillin-tazobactamZosyn
IV: Intravenous

CONCLUSION

Thus, because of its invasive nature, Ludwig’s angina needs early recognition and treatment. The appropriate use of parenteral antibiotics, airway protection techniques, and formal surgical drainage of the infection remain the standard protocols of treatment in advanced cases of Ludwig’s angina.

Conflicts of interest

Source of support: Nil

Conflict of interest: None