Comparison of Bioactive Glass Bone Graft (Putty) with Autologous Platelet-rich Fibrin in the Treatment of Intrabony Defects
Ashwini A Apine, Shivaprasad Bilichodmath, Nimmi Janardhanan
Density analysis, Film grid, Intrabony defects, NovaBone® putty, Platelet-rich fibrin
Citation Information :
Apine AA, Bilichodmath S, Janardhanan N. Comparison of Bioactive Glass Bone Graft (Putty) with Autologous Platelet-rich Fibrin in the Treatment of Intrabony Defects. J Health Sci Res 2020; 11 (2):42-52.
Aim and objective: This study was aimed to clinically and radiographically evaluate and compare the efficacy of bioactive glass bone graft (NovaBone® putty) and autologous platelet-rich fibrin (PRF) in the treatment of periodontal intrabony defects.
Materials and methods: A total of 30 intrabony defects were treated in 11 patients. Defects were randomly divided into group I (n = 15; NovaBone® putty) and group II (n = 15; PRF). Clinical parameters evaluated were plaque index, gingival index, probing depth (PD), clinical attachment level (CAL), gingival recession (GR), and cementoenamel junction from a fixed reference point (acrylic stent). Radiographic parameters such as radiographic defect depth, radiographic defect fill, percentage defect fill, and radiographic bone density analysis were recorded and analyzed using radiovisiography (RVG) and film grid. All the parameters were recorded at baseline, 3-, 6-, and 9-month visits.
Results: The mean PD reduction, gain in CAL, and mean GR were 4.067, 4.06, and 0.2 mm, respectively, for group I, whereas that of group II, they were 3.467, 3.00, and 0.14 mm, respectively. The mean radiographic defect depth and mean percentage defect fill were, 1.867 mm and 30.7%, respectively, in group I at 9 months. And that of group II, they were 1.466 mm and 27.5%, respectively, at 9 months. The improvement of clinical and radiographic parameters at sites treated with NovaBone® putty was better compared to that of sites treated with PRF, but the differences were statistically not significant.
Conclusion: The results of the present study emphasize that the regenerative potential of NovaBone® putty was predictable and equivalent to autologous platelet-rich fibrin. Autologous platelet-rich fibrin can be considered as a reliable periodontal regenerative material, which is inexpensive and readily available.
Key message: Autologous PRF can be considered as an inexpensive alternative to the NovaBone® putty bone graft material.
Socransky SS, Haffajee AD. The nature of periodontal diseases. Ann Periodontol 1997;2(1):3–10. DOI: 10.1902/annals.1918.104.22.168.
Caton J, Nyman S, Zander H. Histometric evaluation of periodontal surgery. II. Connective tissue attachment levels after four regenerative procedures. J Clin Periodontol 1980;7(3):224–231. DOI: 10.1111/j.1600-051x.1980.tb01965.x.
Melcher AH. On the repair potential of periodontal tissues. J Periodontol 1976;47(5):256–260. DOI: 10.1902/jop.1922.214.171.1246.
Newmann MG, Takei HH, Klokkevold PR, et al. Clinical Periodontology, 10th ed. Noida: Elsevier; 2006. pp. 968–985.
Hench LL, Paschal1 HA. Direct chemical bond of bioactive glass-ceramic materials to bone and muscle. J Biomed Mater Res 1973;7(3):25–42. DOI: 10.1002/jbm.820070304.
El-Ghannam A, Ducheyne D, Shapiro IM. Formation of surface reaction products on bioactive glass and their effects on the expression of the osteoblastic phenotype and the deposition of mineralized extracellular matrix. Biomaterials 1997;18(4):295–303. DOI: 10.1016/s0142-9612(96)00059-2.
Kenney EB, Lekovic V, SaFerreira JC, et al. Bone formation within porous hydroxylapatite implants in human periodontal defects. J Periodontol 1986:57(2):76–83. DOI: 10.1902/jop.19126.96.36.199.
Froum SJ, Mea AW, Dennis T. Comparison of bioactive glass synthetic bone graft particles and open debridement in the treatment of human periodontal defects. A clinical study. J Periodontol 1998;69(6):698–709. DOI: 10.1902/jop.19188.8.131.528.
Sharma A, Pradeep AR. Autologous platelet rich fibrin in the treatment of mandibular degree II furcation defects: a randomized clinical trial. J Periodontol 2011;82(10):1396–1403. DOI: 10.1902/jop.2011.100731.
Thorat MK, Pradeep AR, Pallavi B. Clinical effects of autologous platelet-rich fibrin in the treatment of intra-bony defects: a controlled clinical trial. J Clin Periodontol 2011;38(10):925–932. DOI: 10.1111/j.1600-051X.2011.01760.x.
Kaur M, Ramakrishnan T, Amblavanan N, et al. Effect of platelet-rich plasma and bioactive glass in the treatment of intrabony defects—a split-mouth study in humans. Braz J Oral Sci 2010;9(2):108–114.
Mazor Z, Horowitz RA, Del Corso M, et al. Sinus floor augmentation with simultaneous implant placement using Choukroun's platelet rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months. J Periodontol 2009;80(12):2056–2064. DOI: 10.1902/jop.2009.090252.
Simon BI, Zatcoff AL, Kong JJ, et al. Clinical and histological comparison of extraction socket healing following the use of autologous platelet-rich fibrin matrix (PRFM) to ridge preservation procedures employing demineralized freeze dried bone allograft material and membrane. Open Dent J 2009;3:92–99. DOI: 10.2174/1874210600903010092.
Sclafani AP, Saman M. Platelet-rich fibrin matrix for facial plastic surgery. Facial Plast Surg Clin North Am 2012;20(2):177–186. DOI: 10.1016/j.fsc.2012.02.004.
Choukroun JI, Braccini F, Diss A, et al. Influence of platelet rich fibrin (PRF) on proliferation of human preadipocytes and tympanic keratinocytes: a new opportunity in facial lipostructure (Coleman's technique) and tympanoplasty? Rev Laryngol Otol Rhinol (Bord) 2007;128(1–2):27–32.
Khiste SV, Tari RN. Platelet-rich fibrin as a biofuel for tissue regeneration. ISRN Biomater 2013;Article ID 627367:1–6. DOI: 10.5402/2013/627367.
Sanchez M, Anitua E, Azofra J, et al. Comparison of surgically repaired achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med 2007;35(2):245–251. DOI: 10.1177/0363546506294078.
Haleem AM, Singergy AA, Sabry D, et al. The clinical use of human culture–expanded autologous bone marrow mesenchymal stem cells transplanted on platelet-rich fibrin glue in the treatment of articular cartilage defects: a pilot study and preliminary results. Cartilage 2010;1(4):253–261. DOI: 10.1177/1947603510366027.
Silness J, Loe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964;22:121–135. DOI: 10.3109/00016356408993968.
Loe H, Silness J. Periodontal disease in pregnancy. I. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964;22:533–521.
Choukroun J, Adda F, Schoeffler C, et al. Une opportunité en paro-implantologie: Le PRF. Implantodontie 2000;42:55–62. French.
Mengel R, Soffner M, Jacoby LF. Bioabsorbable membrane and bioactive glass in the treatment of intrabony defects in patients with generalized aggressive periodontitis: results of a 12-month clinical and radiological study. J Periodontol 2003;74(6):899–908. DOI: 10.1902/jop.2003.74.6.899.
Sculean A, Giovanni B, Giovanni C, et al. Clinical evaluation of an enamel matrix protein derivative combined with a bioactive glass for the treatment of intrabony periodontal defects in humans. J Periodontol 2002;73(4):401–408. DOI: 10.1902/jop.2002.73.4.401.
Grover V, Kapoor A, Malhotra R, et al. Evaluation of the efficacy of a bioactive synthetic graft material in the treatment of intrabony periodontal defects. J Indian Soc Periodontol 2013;17(1):104–110. DOI: 10.4103/0972-124X.107484.
Ong MM, Eber RM, Korsnes MI. Evaluation of a bioactive glass alloplast in treating periodontal intrabony defects. J Periodontol 1998;69(12):1346–1354. DOI: 10.1902/jop.19184.108.40.2066.
Polimeni G, Xiropaidis AV, Wikesjo UM. Biology and principles of periodontal wound healing/regeneration. Periodontol 2000 2006;41:30–47. DOI: 10.1111/j.1600-0757.2006.00157.x.
Park JS, Suh JJ, Choi SH, et al. Effects of pretreatment clinical parameters on bioactive glass implantation in intrabony periodontal defects. J Periodontol 2001;72(6):730–740. DOI: 10.1902/jop.2001.72.6.730.
Garret S, Gary B. Periodontal regeneration: a review of flap management. Periodontol 2000 1993;1(1):100–108.
Bowers GM, Chadroff B, Carnevale R, et al. Histologic evaluation of new attachment apparatus formation in humans. Part I. J Periodontol 1989;60(12):664–674. DOI: 10.1902/jop.19220.127.116.114.
Ducheyne P, Brown S, Blumenthal N, et al. Bioactive glasses, aluminum oxide and titanium. Ion transport phenomenon and surface analysis. Ann N Y Acad Sci 1988;523:257–261. DOI: 10.1111/j.1749-6632.1988.tb38517.x.
Kitsugi T, Nakamara T, Oka M, et al. Bone-bonding behavior of three heat-treated silica gels implanted in mature rabbit bone. Calcif Tissue Int 1995;57(2):155–160. DOI: 10.1007/BF00298437.
Greenspan DC, Zhong JP, La Torre GP. The evaluation of surface structure of bioactive glasses in-vitro. In: Wilson J, Hench LL, Greenspan D, editors. Proceedings of the eight international symposium on ceramics in medicine. Bioceramics, vol. 8. London: Pergamon Press; 1995. pp. 477–482.
Hench LL. Bioactive ceramics. Ann N Y Acad Sci 1988;523:54–71. DOI: 10.1111/j.1749-6632.1988.tb38500.x.
Wilson J, Low SB. Bioactive ceramics for periodontal treatment: comparative studies in the Patus monkey. J Appl Biomater 1992;3(2):123–129. DOI: 10.1002/jab.770030208.
Choukroun J, Diss A, Simonpieri A. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101(3):e56–60. DOI: 10.1016/j.tripleo.2005.07.011.